HIV blocking gene identified

Tue, Mar 4, 2008


A team of researchers at the University of Alberta has discovered a gene that is able to block HIV, and in turn prevent the onset of AIDS.

Stephen Barr, a molecular virologist in the Department of Medical Microbiology and Immunology, says his team has A team of researchers at the University of Alberta has discovered a gene that is able to block HIV, and in turn prevent the onset of AIDS.

“When we put this gene in cells, it prevents the assembly of the HIV virus,” said Barr, a postdoctoral fellow. “This means the virus cannot get out of the cells to infect other cells, thereby blocking the spread of the virus.”

Barr and his team also prevented cells from turning on TRIM22 – provoking an interesting phenomenon: the normal response of interferon, a protein that co-ordinates attacks against viral infections, became useless at blocking HIV infection.

“This means that TRIM22 is an essential part of our body’s ability to fight off HIV. The results are very exciting because they show that our bodies have a gene that is capable of stopping the spread of HIV.”

One of the greatest challenges in battling HIV is the virus’ ability to mutate and evade medications. Antiretroviral drugs introduced during the late 1990s interfere with HIV’s ability to produce new copies of itself – and even they are beneficial, the drugs are unable to eradicate the virus. Barr and his team have discovered a gene that could potentially do the job naturally.

“There are always newly emerging drug-resistant strains of HIV so the push has been to develop more natural means of blocking the virus. The discovery of this gene, which is natural in our cells, might provide a different avenue,” said Barr. “The gene prevents the assembly of the virus so in the future the idea would be to develop drugs or vaccines that can mimic the effects of this gene.”

“We are currently trying to figure out why this gene does not work in people infected with HIV and if there is a way to turn this gene on in those individuals,” he added. “We hope that our research will lead to the design of new drugs, or vaccines that can halt the person-to-person transmission of HIV and the spread of the virus in the body, thereby blocking the onset of AIDS.”

The researchers are now investigating the gene’s ability to battle other viruses.

Barr’s research is funded by the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council and the Alberta Heritage Foundation for Medical Research. The findings are published in the Public Library of Science Pathogens.

This post was written by:

- who has written 290 posts on The Everything Blog.

I'm a 22 year old guy blogging about things which I feel are important. Currently pursuing B.Tech in Biotechnology.

Contact the author

11 Comments For This Post

  1. AIDS Drugs Says:

    Yea the test you can order now to see if you have anti HIV genes is very cool.

  2. Sabina Digman Says:

    Some good ideas here. Still looking for additional info on natural health and would appreciate any recommendations. Thank You!

  3. Zachery Santillo Says:

    Thanks for your thoughts. One thing really noticed is that often banks and financial institutions have in mind the spending patterns of consumers and as well understand that most of the people max out their credit cards around the vacations. They smartly take advantage of this kind of fact and start flooding your current inbox plus snail-mail box together with hundreds of no interest APR credit cards offers just after the holiday season finishes. Knowing that in case you are like 98% in the American community, you’ll get at the one opportunity to consolidate personal credit card debt and transfer balances to 0 interest rate credit cards.

  4. Air Jordan Heels Says:

    Good story Thank you so many for sharing this post.Your views actually open my mind.

  5. factory unlocked iphone Says:

    Hey! This post could not be written any better! Reading this post reminds me of my old room mate! He always kept talking about this. I will forward this article to him. Fairly certain he will have a good read. Many thanks for sharing!

  6. odbior inwestycji Says:

    Today, while skup olesnica We was at the job, my relative stole my personal iphone and also tested to determine if it can survive a twenty five foot lower, just therefore she generally is a youtube experiencing. My iPad has become destroyed and she’s 83 views. I know this is entirely off of topic but I had to reveal it along with someone!

  7. build a website for free with free domain Says:

    I have read a few excellent stuff here. Certainly price bookmarking for revisiting. I wonder how a lot attempt you place to create the sort of excellent informative web site.

  8. factory unlock iphone Says:

    A GSM secured Sim will be organized towards hyperlink to a new verizon wireless, Citrus, AT&T, Planting season, even more. From conducting this method, men and women are releasing SIM cards which they have absolutely no tendency while backlinking to help services on the group. It really is a lot of employs, what is going on as to why opening how to unlock iphone software is aware of fitness center phone meeting places. The particular factory unlock iphone Four unlock iphone 4ing, necessitates getting a golf hole on the device baseband bootloader, and thereby, modifying the way the particular apple company factory unlock iphone Some instrument raises upwards and cargo firmware A few.A unlock iphone 4.

  9. Courtney Gola Says:

    Between me and my husband we’ve owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I’ve settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

  10. proenutrition Says:

    Wouldn’t a person believe that all these “Ranchero” permutations would flip on the lightbulb in someone’s head at Ford?

  11. servidores dedicados Says:

    Allen West for V.P.! Could not be stopped by any obama machine

1 Trackbacks For This Post

  1.   HIV blocking gene identified by Says:

    [...] post by Mayank delivered by Medtrials and [...]