RSS

Scientists make beating heart in laboratory

Tue, Jan 22, 2008

Biology, Biotech, Science and Technology

MINNEAPOLIS / ST. PAUL (January, 13 2008) — University of Minnesota researchers have created a beating heart in the laboratory.

By using a process called whole organ decellularization, scientists from the University of Minnesota Center for Cardiovascular Repair grew functioning heart tissue by taking dead rat and pig hearts and reseeding them with a mixture of live cells. The research will be published online in the January 13 issue of Nature Medicine.

“The idea would be to develop transplantable blood vessels or whole organs that are made from your own cells,” said Doris Taylor, Ph.D., director of the Center for Cardiovascular Repair, Medtronic Bakken professor of medicine and physiology, and principal investigator of the research.

Nearly 5 million people live with heart failure, and about 550,000 new cases are diagnosed each year in the United States. Approximately 50,000 United States patients die annually waiting for a donor heart.

While there have been advances in generating heart tissue in the lab, creating an entire 3-dimensional scaffold that mimics the complex cardiac architecture and intricacies, has always been a mystery, Taylor said.

It seems decellularization may be a solution – essentially using nature’s platform to create a bioartifical heart, she said.

Decellularization is the process of removing all of the cells from an organ – in this case an animal cadaver heart – leaving only the extracellular matrix, the framework between the cells, intact.

After successfully removing all of the cells from both rat and pig hearts, researchers injected them with a mixture of progenitor cells that came from neonatal or newborn rat hearts and placed the structure in a sterile setting in the lab to grow.

The results were very promising, Taylor said. Four days after seeding the decellularized heart scaffolds with the heart cells, contractions were observed. Eight days later, the hearts were pumping.

“Take a section of this ‘new heart’ and slice it, and cells are back in there,” Taylor said. “The cells have many of the markers we associate with the heart and seem to know how to behave like heart tissue.”

“We just took nature’s own building blocks to build a new organ,” said Harald C. Ott, M.D., co-investigator of the study and a former research associate in the center for cardiovascular repair, who now works at Massachusetts General Hospital. “When we saw the first contractions we were speechless.”

Researchers are optimistic this discovery could help increase the donor organ pool.

In general, the supply of donor organs is limited and once a heart is transplanted, individuals face life-long immunosuppression, often trading heart failure for high blood pressure, diabetes, and kidney failure, Taylor said.

Researchers hope that the decellularization process could be used to make new donor organs. Because a new heart could be filled with the recipient’s cells, researchers hypothesize it’s much less likely to be rejected by the body. And once placed in the recipient, in theory the heart would be nourished, regulated, and regenerated similar to the heart that it replaced.

“We used immature heart cells in this version, as a proof of concept. We pretty much figured heart cells in a heart matrix had to work,” Taylor said. “Going forward, our goal is to use a patient’s stem cells to build a new heart.”

Although heart repair was the first goal during research, decellularization shows promising potential to change how scientists think about engineering organs, Taylor said.

“It opens a door to this notion that you can make any organ: kidney, liver, lung, pancreas – you name it and we hope we can make it,” she said.

Researchers of the Center for Cardiovascular Repair team were assisted in their study by researchers from the University of Minnesota Department of Biomedical Engineering, who helped analyze data.

The study was funded by the Medtronic Foundation Endowment and a faculty research development grant from the University of Minnesota Academic Health Center.

beatingheart

Source

This post was written by:

- who has written 290 posts on BT-G.com: The Everything Blog.

I'm a 22 year old guy blogging about things which I feel are important. Currently pursuing B.Tech in Biotechnology.

Contact the author

18 Comments For This Post

  1. Phil Says:

    Passing through and wanted to say hello

  2. studen Says:

    Wow i have to say this could help a lot of people

  3. Alex Says:

    I found your site on technorati and read a few of your other posts. Keep up the good work. I just added your RSS feed to my Google News Reader. Looking forward to reading more from you down the road!

  4. Extenze Says:

    I hope they keep at it. Millions could be saved.

  5. Droneeroofoks Says:

    biotech-geek.com – great domain name for blog like this)))

  6. Company Formation India Says:

    The info you have given here really makes my head spin, keep it going

  7. Autokomis Says:

    One thing is that one of the most prevalent incentives for utilizing your card is a cash-back and also rebate supply. Generally, you’ll have access to 1-5% back on various acquisitions. Depending on the credit cards, you may get 1% returning on most expenses, and 5% in return on expenditures made going to convenience stores, filling stations, grocery stores and ‘member merchants’.

  8. Joey Scarce Says:

    A powerful share, I just given this onto a colleague who was doing just a little analysis on this. And he the truth is bought me breakfast because I found it for him.. smile. So let me reword that: Thnx for the deal with! However yeah Thnkx for spending the time to debate this, I feel strongly about it and love reading extra on this topic. If possible, as you change into expertise, would you mind updating your blog with more particulars? It is highly useful for me. Massive thumb up for this blog publish!

  9. tapety Says:

    enter the code from the coupon

  10. Booker Koberg Says:

    Some genuinely fantastic content on this web site, thanks for contribution. “Give me the splendid silent sun with all his beams full-dazzling.” by Walt Whitman.

  11. Witiou Says:

    Oh my, Got my supplies today and I really like refilling it myself. I find all cartomizers to be a little weak tasting, except for the greensmoke carts….I wonder who makes theirs? Well I had tons of carts to fit my batteries. So far I have 2 vapor King, long batteries, just got your manuel battery (like it) and 2 smoke tips which are all the same batteries. The only different one’s are my Blu and my greensmoke. I think I have enough. I like having them all on me according to what mood I’m in and what I like to smoke. So far the KR808d-1 I think is a great battery. I think I’m turning into a vapor monster… Thanks for answeringSharon Holiday

  12. Brandi Zaya Says:

    You recognize therefore significantly with regards to this topic, produced me personally believe it from so many various angles. Its like women and men don’t seem to be fascinated except it’s something to do with Lady gaga! Your own stuffs great. Always take care of it up!

  13. Annonces gay Says:

    It is a these kinds of great post, and i want to partage it on my personal weblog gay if you give me the accord for sharing !

  14. proe nutrition Says:

    I believe this web site has obtained some quite exceptional info for everyone . “Years wrinkle the skin, but to offer up enthusiasm wrinkles the soul.” by Samuel Ullman.

  15. web monitoring Says:

    Fantastic web-site. Many helpful data right here. I’m sending it to some buddies ans additionally sharing in delightful. And definitely, thanks for your personal sweat!

  16. administracion de vps Says:

    Wonderful San-as often! I really like the the macro shot! x

  17. premium account Says:

    I did the same modification to your Pacer station wagon when i was thirteen. In 1/25 scale naturally.

  18. http://www.samba.sanitarne.waw.pl/detail/29222/dan-hilston.html Says:

    Hello just wanted to give you a quick heads up. The text in your post seem to be running off the screen in Opera. I’m not sure if this is a formatting issue or something to do with web browser compatibility but I thought I’d post to let you know. The layout look great though! Hope you get the issue fixed soon. Kudos

3 Trackbacks For This Post

  1.   Scientists make beating heart in laboratory by medTRIALS.info Says:

    [...] post by Mayank delivered by Medtrials and [...]

  2. Midwest HighTech » Blog Archive » Laboratory grown heart begins to beat Says:

    [...] disease is the #1 killer in America, even larger than cancer. Biotech-Geek cites some numbers that drive the magnitude of the potential benefits of this treatment: [...]

  3. http://biotech-geek.com/blog2/2008/01/22/scientists-make-beating-heart-in-laboratory/ Says:

    [...] writing a post about this entry http://biotech-geek.com/blog2/2008/01/22/scientists-make-beating-heart-in-laboratory/ Stay [...]